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KMID : 1188320210150050742
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Gut and Liver
2021 Volume.15 No. 5 p.742 ~ p.751
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Clinical Characteristics and Long-term Prognosis of Elderly-Onset Ulcerative Colitis in a Population-Based Cohort in the Songpa-Kangdong District of Seoul, Korea
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Park Sang-Hyoung
Jeong Seung-Kyu
Lee Ji-Hyun
Rhee Kyoung-Hoon
Kim Young-Ho
Hong Sung-Noh
Kim Kyung-Ho
Seo Seung-In
Cha Jae-Myung
Park Sun-Yong
Park Hyun-Ju
Kim Joo-Sung
Im Jong-Pil
Yoon Hyuk
Kim Sung-Hoon
Jang Ji-Sun
Kim Jeong-Hwan
Suh Seong-O
Kim Young-Kyun
Ye Byong-Duk
Yang Suk-Kyun
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Abstract
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Background/Aims: We aimed to evaluate the clinical characteristics and long-term prognosis of elderly-onset ulcerative colitis (EOUC) in Korean patients over a 30-year period using a wellestablished population-based cohort in the Songpa-Kangdong district of Seoul, Korea.
Methods: Clinical characteristics and prognosis were compared between two groups: EOUC, defined as UC diagnosed in individuals aged ≥60 years and non-EOUC (N-EOUC), defined as UC diagnosed in individuals aged 18 to 59 years.
Results: We identified 99 patients with EOUC (10.3%) and 866 patients with N-EOUC (89.7%) between 1986 and 2015. During the median follow-up of 104.5 months, the overall exposure to medications was comparable between patients with EOUC and N-EOUC (p=0.091 for corticosteroids, p=0.794 for thiopurines, and p=0.095 for anti-tumor necrosis factor agents). The cumulative risks of disease outcomes were also comparable between patients with EOUC and N-EOUC (22.4% vs 30.4% for proximal disease extension [p=0.351], 11.9% vs 18.1% for hospitalization [p=0.240], and 2.3% vs 1.8% for colectomy [p=0.977]) at 10 years after diagnosis. Multivariate Cox regression analysis revealed that corticosteroid use at diagnosis was an independent predictor of proximal disease extension (hazard ratio [HR], 6.216; 95% confidence interval [CI], 1.314 to 28.826) and hospitalization (HR, 11.241; 95% CI, 3.027 to 41.742) in patients with EOUC.
Conclusions: In this population-based study from Korea, the pattern of medication use seemed comparable between the EOUC and N-EOUC groups. Moreover, patients with EOUC and those with N-EOUC have a similar disease course in terms of proximal disease extension, hospitalization, and colectomy.
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KEYWORD
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Colitis, ulcerative, Aged, Prognosis, Korea
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